/* ============================================================
   McGavin Lab — design tokens
   Palette: white / sky blue, professional & clinical
   Signature motif: phospholipid bilayer + efflux pump diagram
   (gold/teal/rust tokens below are reserved for that one diagram)
   ============================================================ */

@import url('https://fonts.googleapis.com/css2?family=Fraunces:ital,opsz,wght@0,9..144,400;0,9..144,500;0,9..144,600;1,9..144,500;1,9..144,600&family=IBM+Plex+Sans:wght@400;500;600&family=IBM+Plex+Mono:wght@400;500&display=swap');

:root{
  --paper: #F6FAFD;
  --paper-dim: #EAF3FA;
  --white: #FFFFFF;
  --ink: #13263B;
  --ink-soft: #4E6478;
  --line: #D7E6F1;

  /* primary UI accent */
  --sky: #2C7BC2;
  --sky-dark: #1B5D97;
  --sky-pale: #E4F1FB;

  /* reserved strictly for the membrane/efflux-pump diagram */
  --gold: #B8862E;
  --gold-soft: #E7D3A5;
  --teal: #3E7C74;
  --teal-dark: #24504A;
  --rust: #A5432F;

  --serif: 'Fraunces', Georgia, serif;
  --sans: 'IBM Plex Sans', -apple-system, BlinkMacSystemFont, 'Segoe UI', sans-serif;
  --mono: 'IBM Plex Mono', 'SFMono-Regular', Consolas, monospace;

  --maxw: 1120px;
}

*, *::before, *::after{ box-sizing: border-box; }

html{ scroll-behavior: smooth; }

body{
  margin: 0;
  background: var(--paper);
  color: var(--ink);
  font-family: var(--sans);
  font-size: 16px;
  line-height: 1.6;
  -webkit-font-smoothing: antialiased;
}

img{ max-width: 100%; display: block; }

a{ color: inherit; }

.wrap{
  max-width: var(--maxw);
  margin: 0 auto;
  padding: 0 32px;
}

@media (max-width: 640px){
  .wrap{ padding: 0 26px; }
}
@media (max-width: 420px){
  .wrap{ padding: 0 22px; }
}

/* ---------- Skip link ---------- */
.skip-link{
  position: absolute;
  left: 12px;
  top: -48px;
  background: var(--ink);
  color: var(--white);
  font-family: var(--mono);
  font-size: 0.8rem;
  padding: 10px 16px;
  border-radius: 4px;
  z-index: 999;
  transition: top .15s ease;
}
.skip-link:focus{ top: 12px; }

/* ---------- Focus states ---------- */
a:focus-visible, button:focus-visible{
  outline: 2px solid var(--sky);
  outline-offset: 3px;
}

@media (prefers-reduced-motion: reduce){
  *{ animation-duration: 0.001ms !important; animation-iteration-count: 1 !important; transition-duration: 0.001ms !important; scroll-behavior: auto !important; }
}

/* ---------- Type ---------- */
h1, h2, h3, h4{
  font-family: var(--serif);
  font-weight: 600;
  line-height: 1.12;
  margin: 0 0 0.5em;
  color: var(--ink);
}

h1{ font-size: clamp(2.4rem, 5vw, 3.8rem); letter-spacing: -0.01em; }
h2{ font-size: clamp(1.7rem, 3vw, 2.3rem); }
h3{ font-size: 1.25rem; }

p{ margin: 0 0 1em; color: var(--ink-soft); text-wrap: pretty; }

.eyebrow{
  font-family: var(--mono);
  font-size: 0.72rem;
  letter-spacing: 0.14em;
  text-transform: uppercase;
  color: var(--sky-dark);
  display: inline-flex;
  align-items: center;
  gap: 10px;
  margin-bottom: 14px;
}
.eyebrow::before{
  content: '';
  width: 22px; height: 1px;
  background: var(--sky);
}

.lede{
  font-size: 1.15rem;
  color: var(--ink-soft);
  max-width: 62ch;
}

/* ---------- Header / nav ---------- */
.site-header{
  position: sticky;
  top: 0;
  z-index: 50;
  background: rgba(255, 255, 255, 0.92);
  backdrop-filter: blur(6px);
  border-bottom: 1px solid var(--line);
  box-shadow: 0 1px 0 rgba(19, 38, 59, 0.02), 0 8px 24px rgba(19, 38, 59, 0.04);
}

.site-header .wrap{
  display: flex;
  align-items: center;
  justify-content: space-between;
  height: 76px;
}

.brand{
  display: flex;
  align-items: center;
  gap: 10px;
  text-decoration: none;
  font-family: var(--serif);
  font-weight: 600;
  font-size: 1.25rem;
  color: var(--ink);
}
.brand-logo{ height: 34px; width: auto; display: block; }
.brand .brand-mark{
  color: var(--sky);
  font-style: italic;
  font-weight: 500;
}

nav.primary{
  display: flex;
  gap: 2px;
}
nav.primary a{
  font-family: var(--mono);
  font-size: 0.78rem;
  letter-spacing: 0.06em;
  text-transform: uppercase;
  text-decoration: none;
  color: var(--ink-soft);
  padding: 10px 14px;
  border-radius: 5px;
  position: relative;
  transition: color .15s ease, background .15s ease;
}
nav.primary a:hover{ color: var(--sky-dark); background: var(--sky-pale); }
nav.primary a.active{ color: var(--sky-dark); background: var(--sky-pale); font-weight: 500; }
nav.primary a.active::after{
  content: '';
  position: absolute;
  left: 14px; right: 14px; bottom: 3px;
  height: 2px;
  background: var(--sky);
  border-radius: 2px;
}

.nav-toggle{
  display: none;
  background: none;
  border: 1px solid var(--line);
  border-radius: 4px;
  padding: 8px 10px;
  font-family: var(--mono);
  font-size: 0.8rem;
  cursor: pointer;
  transition: border-color .15s ease, color .15s ease;
}
.nav-toggle:hover{ border-color: var(--sky); color: var(--sky-dark); }

@media (max-width: 860px){
  nav.primary{
    display: none;
    position: absolute;
    top: 76px; left: 0; right: 0;
    background: var(--white);
    border-bottom: 1px solid var(--line);
    flex-direction: column;
    padding: 8px 20px 16px;
  }
  nav.primary.open{ display: flex; }
  nav.primary a{ padding: 12px 4px; border-bottom: 1px solid var(--paper-dim); border-radius: 0; }
  nav.primary a.active::after{ display: none; }
  .nav-toggle{ display: inline-block; }
}

/* ---------- Buttons / links ---------- */
.btn{
  display: inline-flex;
  align-items: center;
  gap: 8px;
  font-family: var(--mono);
  font-size: 0.8rem;
  letter-spacing: 0.04em;
  text-transform: uppercase;
  text-decoration: none;
  padding: 13px 22px;
  border-radius: 5px;
  border: 1px solid var(--ink);
  color: var(--ink);
  transition: background .18s ease, color .18s ease, border-color .18s ease, transform .18s ease, box-shadow .18s ease;
}
.btn:hover{ background: var(--ink); color: var(--white); transform: translateY(-1px); box-shadow: 0 6px 16px rgba(19, 38, 59, 0.18); }
.btn.solid{ background: var(--sky); color: var(--white); border-color: var(--sky); }
.btn.solid:hover{ background: var(--sky-dark); border-color: var(--sky-dark); box-shadow: 0 6px 18px rgba(44, 123, 194, 0.28); }

.text-link{
  text-decoration: underline;
  text-decoration-color: var(--sky);
  text-underline-offset: 4px;
  text-decoration-thickness: 1.5px;
  transition: text-decoration-color .15s ease, color .15s ease;
}
.text-link:hover{ text-decoration-color: var(--sky-dark); color: var(--sky-dark); }

/* ---------- Hero ---------- */
.hero{
  padding: 72px 0 88px;
  border-bottom: 1px solid var(--line);
  position: relative;
}
.hero .wrap{
  display: grid;
  grid-template-columns: 0.9fr 1.1fr;
  gap: 72px;
  align-items: center;
}
.hero h1{ font-size: clamp(2.2rem, 4.2vw, 3.2rem); }
.hero .lede{ font-size: 1.05rem; }
@media (max-width: 900px){
  .hero .wrap{ grid-template-columns: 1fr; }
}

.hero-diagram{
  background: var(--white);
  border: 1px solid var(--line);
  border-radius: 10px;
  padding: 20px;
  box-shadow: 0 16px 36px rgba(19, 38, 59, 0.07);
}
.hero-diagram figcaption{
  font-family: var(--mono);
  font-size: 0.7rem;
  color: var(--ink-soft);
  margin-top: 10px;
  letter-spacing: 0.02em;
}

.hero-cta{
  display: flex;
  gap: 14px;
  margin-top: 28px;
  flex-wrap: wrap;
}

/* ---------- Section rhythm ---------- */
section{ padding: 76px 0; }
section.tight{ padding: 48px 0; }
.section-head{
  display: flex;
  justify-content: space-between;
  align-items: flex-end;
  gap: 24px;
  margin-bottom: 40px;
  flex-wrap: wrap;
}

.divider{
  border: none;
  border-top: 1px solid var(--line);
  margin: 0;
}

.bilayer-rule{
  height: 14px;
  width: 100%;
  background-image: radial-gradient(circle, var(--sky-pale) 2.5px, transparent 2.6px);
  background-size: 22px 14px;
  background-position: center;
  opacity: 1;
  margin: 0;
}

/* ---------- Cards ---------- */
.card-grid{
  display: grid;
  grid-template-columns: repeat(3, 1fr);
  gap: 28px;
}
@media (max-width: 860px){ .card-grid{ grid-template-columns: 1fr; } }

.card{
  background: var(--white);
  border: 1px solid var(--line);
  border-radius: 10px;
  padding: 30px 28px;
  position: relative;
  box-shadow: 0 1px 2px rgba(19, 38, 59, 0.03);
  transition: border-color .2s ease, box-shadow .2s ease, transform .2s ease;
}
.card:hover{
  border-color: var(--sky);
  box-shadow: 0 14px 32px rgba(44, 123, 194, 0.14);
  transform: translateY(-3px);
}
.card .num{
  font-family: var(--mono);
  font-size: 0.75rem;
  color: var(--sky-dark);
  display: block;
  margin-bottom: 14px;
}
.card h3{ margin-bottom: 10px; }
.card p{ font-size: 0.95rem; margin-bottom: 0; }
.card p:last-child{ margin-bottom: 0; }

/* ---------- Panel / band ---------- */
.band{
  background: var(--ink);
  color: var(--paper);
}
.band h2, .band .eyebrow{ color: var(--white); }
.band .eyebrow::before{ background: var(--sky); }
.band p{ color: #A9C2D9; }

/* ---------- Team ---------- */
.pi-block{
  display: grid;
  grid-template-columns: 260px 1fr;
  gap: 44px;
  align-items: center;
}
@media (max-width: 760px){ .pi-block{ grid-template-columns: 1fr; } }
.pi-block:hover{ border-color: var(--sky); box-shadow: 0 14px 32px rgba(44, 123, 194, 0.14); transform: translateY(-3px); }
.pi-polaroid{
  display: inline-block;
  background: var(--white);
  padding: 10px 10px 26px;
  border: 1px solid var(--line);
  box-shadow: 0 10px 24px rgba(19,38,59,0.12), 0 2px 5px rgba(19,38,59,0.06);
  transform: rotate(-1.5deg);
  transition: transform .2s ease, box-shadow .2s ease;
}
.pi-block:hover .pi-polaroid{ transform: rotate(0deg) scale(1.03); box-shadow: 0 16px 32px rgba(19, 38, 59, 0.16), 0 3px 6px rgba(19, 38, 59, 0.08); }
.pi-photo{
  border-radius: 10px;
  overflow: hidden;
  border: 1px solid var(--line);
  box-shadow: 0 12px 28px rgba(19, 38, 59, 0.08);
}
.pi-photo img{ width: 100%; height: auto; }

.member-grid{
  display: grid;
  grid-template-columns: repeat(3, 1fr);
  gap: 24px;
}
@media (max-width: 760px){ .member-grid{ grid-template-columns: 1fr 1fr; } }
@media (max-width: 500px){ .member-grid{ grid-template-columns: 1fr; } }

.member-card{
  background: var(--white);
  border: 1px solid var(--line);
  border-radius: 10px;
  padding: 22px;
  box-shadow: 0 1px 2px rgba(19, 38, 59, 0.03);
  transition: border-color .2s ease, box-shadow .2s ease, transform .2s ease;
}
.member-card:hover{
  border-color: var(--sky);
  box-shadow: 0 14px 32px rgba(44, 123, 194, 0.14);
  transform: translateY(-3px);
}
.member-card .polaroid{
  display: inline-block;
  background: var(--white);
  padding: 10px 10px 26px;
  border: 1px solid var(--line);
  box-shadow: 0 10px 24px rgba(19, 38, 59, 0.12), 0 2px 5px rgba(19, 38, 59, 0.06);
  margin-bottom: 18px;
  transform: rotate(-1.5deg);
  transition: transform .3s ease, box-shadow .3s ease;
}
.member-card:nth-child(3n+2) .polaroid{ transform: rotate(1.5deg); }
.member-card:nth-child(3n) .polaroid{ transform: rotate(-0.75deg); }
.member-card:hover .polaroid{ transform: rotate(0deg) scale(1.03); box-shadow: 0 16px 32px rgba(19, 38, 59, 0.16), 0 3px 6px rgba(19, 38, 59, 0.08); }
.member-card .polaroid img{
  width: 168px;
  height: 168px;
  max-width: 100%;
  object-fit: cover;
  display: block;
  border-radius: 1px;
}
.member-card .role{
  font-family: var(--mono);
  font-size: 0.7rem;
  text-transform: uppercase;
  letter-spacing: 0.06em;
  color: var(--sky-dark);
  display: block;
  margin-bottom: 6px;
}
.member-card h4{ font-family: var(--sans); font-weight: 600; font-size: 1rem; margin: 0 0 4px; }
.member-card .meta{ font-size: 0.85rem; color: var(--ink-soft); margin: 0; }

.placeholder-note{
  border: 1px dashed var(--sky);
  background: var(--sky-pale);
  border-radius: 8px;
  padding: 18px 22px;
  font-size: 0.92rem;
  color: var(--ink-soft);
}
.placeholder-note strong{ color: var(--ink); }

/* ---------- Alumni table ---------- */
.alumni-group{ margin-bottom: 36px; }
.alumni-group h3{
  font-family: var(--mono);
  font-weight: 500;
  font-size: 0.85rem;
  text-transform: uppercase;
  letter-spacing: 0.06em;
  color: var(--sky-dark);
  border-bottom: 1px solid var(--line);
  padding-bottom: 10px;
  margin-bottom: 4px;
}
.alumni-list{ list-style: none; margin: 0; padding: 0; }
.alumni-list li{
  padding: 16px 14px;
  margin: 0 -14px;
  border-bottom: 1px solid var(--paper-dim);
  display: grid;
  grid-template-columns: 260px 1fr;
  gap: 16px;
  border-radius: 8px;
  transition: background .15s ease;
}
.alumni-list li:hover{ background: var(--sky-pale); }
@media (max-width: 640px){ .alumni-list li{ grid-template-columns: 1fr; gap: 4px; } }
.alumni-list .name{ font-weight: 600; display: flex; align-items: center; gap: 10px; }
.alumni-list .name-text{ display: block; min-width: 0; }
.alumni-list .avatar{
  width: 32px; height: 32px;
  border-radius: 50%;
  object-fit: cover;
  border: 1px solid var(--line);
  flex-shrink: 0;
}
.alumni-list .yrs{
  font-family: var(--mono);
  font-size: 0.78rem;
  color: var(--ink-soft);
  display: block;
  white-space: nowrap;
}
.alumni-list .detail{ font-size: 0.92rem; color: var(--ink-soft); }
.alumni-list .now{ font-size: 0.85rem; color: var(--sky-dark); }

/* ---------- Publications ---------- */
.pub-list{ list-style: none; margin: 0; padding: 0; }
.pub-item{
  padding: 26px 14px;
  margin: 0 -14px;
  border-bottom: 1px solid var(--line);
  display: grid;
  grid-template-columns: 90px 1fr;
  gap: 20px;
  border-radius: 8px;
  transition: background .15s ease;
}
.pub-item:hover{ background: var(--sky-pale); }
@media (max-width: 640px){ .pub-item{ grid-template-columns: 1fr; gap: 6px; } }
.pub-item .yr{
  font-family: var(--mono);
  color: var(--sky-dark);
  font-size: 0.95rem;
}
.pub-item .cite{ font-size: 0.97rem; color: var(--ink); }
.pub-item .cite .authors{ color: var(--ink-soft); }
.pub-item .cite .journal{ font-style: italic; }
.pub-item .links{ margin-top: 8px; }
.pub-item .links a{ font-family: var(--mono); font-size: 0.78rem; margin-right: 16px; }

.pub-figure{
  margin-top: 16px;
  border: 1px solid var(--line);
  border-radius: 8px;
  overflow: hidden;
  max-width: 640px;
  background: var(--white);
  box-shadow: 0 8px 20px rgba(19, 38, 59, 0.05);
}
.pub-figure img{ width: 100%; height: auto; display: block; }
.pub-figure figcaption{
  font-family: var(--mono);
  font-size: 0.72rem;
  color: var(--ink-soft);
  padding: 8px 12px;
  background: var(--paper-dim);
  border-top: 1px solid var(--line);
}

/* ---------- News ---------- */
.news-list{ list-style: none; margin: 0; padding: 0; }
.news-item{
  display: grid;
  grid-template-columns: 150px 1fr;
  gap: 20px;
  padding: 26px 14px;
  margin: 0 -14px;
  border-bottom: 1px solid var(--line);
  border-radius: 8px;
  transition: background .15s ease;
}
.news-item:hover{ background: var(--sky-pale); }
@media (max-width: 640px){ .news-item{ grid-template-columns: 1fr; gap: 6px; } }
.news-item time{
  font-family: var(--mono);
  font-size: 0.8rem;
  color: var(--sky-dark);
  text-transform: uppercase;
  letter-spacing: 0.04em;
}
.news-item p{ margin: 0; }

/* ---------- Gallery ---------- */
.gallery{
  display: grid;
  grid-template-columns: repeat(4, 1fr);
  gap: 10px;
}
@media (max-width: 760px){ .gallery{ grid-template-columns: repeat(2, 1fr); } }
.gallery a{
  display: block;
  overflow: hidden;
  border-radius: 8px;
}
.gallery img{
  width: 100%;
  height: 220px;
  object-fit: cover;
  border-radius: 8px;
  transition: transform .3s ease;
}
.gallery img:hover{ transform: scale(1.05); }

/* ---------- Contact ---------- */
.contact-grid{
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: 56px;
}
@media (max-width: 800px){ .contact-grid{ grid-template-columns: 1fr; } }
.contact-line{
  display: flex;
  gap: 14px;
  padding: 14px 0;
  border-bottom: 1px solid var(--paper-dim);
}
.contact-line .k{
  font-family: var(--mono);
  font-size: 0.72rem;
  text-transform: uppercase;
  letter-spacing: 0.06em;
  color: var(--sky-dark);
  width: 90px;
  flex-shrink: 0;
  padding-top: 3px;
}
.contact-line a.text-link{ transition: color .15s ease; }
.map-frame{
  border: 1px solid var(--line);
  border-radius: 10px;
  overflow: hidden;
  height: 100%;
  min-height: 320px;
  box-shadow: 0 12px 28px rgba(19, 38, 59, 0.06);
}
.map-frame iframe{ width: 100%; height: 100%; min-height: 320px; border: 0; }

/* ---------- Funding logos ---------- */
.logo-row{
  display: flex;
  align-items: center;
  gap: 40px;
  flex-wrap: wrap;
}
.logo-row img{ height: 56px; width: auto; opacity: 0.75; filter: grayscale(15%); transition: opacity .18s ease, filter .18s ease; }
.logo-row img:hover{ opacity: 1; filter: grayscale(0%); }

/* ---------- Footer ---------- */
footer.site-footer{
  border-top: 1px solid var(--line);
  padding: 48px 0 40px;
  margin-top: 40px;
  background: var(--white);
}
footer.site-footer .wrap{
  display: flex;
  justify-content: space-between;
  align-items: flex-start;
  gap: 24px;
  flex-wrap: wrap;
}
footer.site-footer .addr{
  font-size: 0.88rem;
  color: var(--ink-soft);
  line-height: 1.7;
}
footer.site-footer .fnav{
  display: flex;
  gap: 18px;
  flex-wrap: wrap;
}
footer.site-footer .fnav a{
  font-family: var(--mono);
  font-size: 0.75rem;
  text-transform: uppercase;
  letter-spacing: 0.05em;
  text-decoration: none;
  color: var(--ink-soft);
  transition: color .15s ease;
}
footer.site-footer .fnav a:hover{ color: var(--sky-dark); }
footer.site-footer .copyright{
  font-family: var(--mono);
  font-size: 0.72rem;
  color: var(--ink-soft);
  margin-top: 24px;
}

/* ---------- Page header (interior pages) ---------- */
/* horizontal padding is explicit here: these pages use class="page-head wrap",
   so this replaces .wrap's gutter on the same element (no doubling) and can't be zeroed */
.page-head{
  padding: 56px 32px 44px;
  border-bottom: 1px solid var(--line);
}
.page-head .lede{ margin-top: 10px; }

/* ---------- utility ---------- */
.mt-0{ margin-top: 0; }
.small{ font-size: 0.85rem; color: var(--ink-soft); }

/* ---------- Publication figure lightbox ---------- */
.pub-figure img{ transition: opacity .15s ease; }
.pub-figure img:hover{ opacity: 0.9; }

.lightbox-overlay{
  position: fixed;
  inset: 0;
  background: rgba(19, 38, 59, 0.92);
  display: none;
  align-items: center;
  justify-content: center;
  flex-direction: column;
  z-index: 200;
  padding: 40px 20px;
  cursor: zoom-out;
}
.lightbox-overlay.open{ display: flex; }
.lightbox-img{
  max-width: min(92vw, 1100px);
  max-height: 82vh;
  width: auto;
  height: auto;
  object-fit: contain;
  border-radius: 4px;
  box-shadow: 0 20px 60px rgba(0,0,0,0.4);
  cursor: zoom-out;
}
.lightbox-caption{
  color: var(--paper);
  font-family: var(--mono);
  font-size: 0.8rem;
  margin-top: 16px;
  max-width: 700px;
  text-align: center;
}
.lightbox-close{
  position: absolute;
  top: 20px;
  right: 28px;
  background: none;
  border: none;
  color: var(--paper);
  font-size: 2.2rem;
  line-height: 1;
  cursor: pointer;
  padding: 8px;
}
.lightbox-close:hover{ color: var(--sky); }
@media (max-width: 640px){
  .lightbox-close{ top: 10px; right: 14px; font-size: 1.8rem; }
}

/* ---------- Mobile: fluid type + breathing room ---------- */
@media (max-width: 900px){
  .research-head{ grid-template-columns: 1fr !important; gap: 30px !important; }
  .hero h1{ font-size: clamp(1.85rem, 6.4vw, 2.5rem); }
  .hero .lede, .research-head .lede{ font-size: 1rem; }
  h1, h2, h3{ overflow-wrap: break-word; }
}
@media (max-width: 640px){
  .page-head{ padding: 40px 26px 32px; }
  .hero-diagram{ padding: 12px; }
  section{ padding: 48px 0; }
  section.tight{ padding: 34px 0; }
  .page-head h1{ font-size: clamp(1.5rem, 6.2vw, 2rem); letter-spacing: 0; }
  .page-head .lede, .lede{ font-size: 0.95rem; line-height: 1.7; }
  h2{ font-size: clamp(1.3rem, 5.2vw, 1.7rem); }
  h3{ font-size: 1.08rem; }
  .member-card, .pi-block, .pub-item, .fund-card, .contact-card{ padding: 22px 20px; }
  .section-head{ flex-direction: column; align-items: flex-start; gap: 10px; }
}
@media (max-width: 420px){
  .page-head{ padding: 36px 22px 28px; }
}