Publications

Publications

  • 2026
    Thapa TB, Kuiack RC, McGavin MJ.  Differential pathogenic and commensal response of Staphylococcus aureus and Staphylococcus epidermidis toward chemical signals of human skin. J Bacteriol. 2026 May 21;208(5):e0011926.
    DOI: 10.1128/jb.00119-26PMID: 42017772
    Figure 5 from Thapa et al. 2026: SDS-PAGE and Western blot panels comparing S. aureus and S. epidermidis protein profiles and secreted protein induction under TSB and acidic pH, and in response to palmitic and palmitoleic acid.
    Figure 5, Thapa et al. 2026, J Bacteriol.
  • 2025
    Bonn-Dunbar CM, Olawoye IB, Thukral A, Guthrie JL, McGavin MJ.  Widespread emergence of Staphylococcus aureus with variant FarR regulators and enhanced resistance to antimicrobial fatty acids within clonal complex CC5, CC8, and CC97 strains from human and bovine hosts. Microbiol Spectr. 2025 Dec 2;13(12):e0227825.
    DOI: 10.1128/spectrum.02278-25PMID: 41170987
    Figure 5 from Bonn-Dunbar et al. 2025: phylogenetic tree showing distribution of FarR variants, host, country, and spa type across S. aureus CC5, CC8, and CC97 strains.
    Figure 5, Bonn-Dunbar et al. 2025, Microbiol Spectr.
  • 2025
    LaRock DL, Sherman JD, Qu C, Ngai W, Read TD, McGavin MJ, LaRock CN.  Staphylococcus aureus induces Gasdermin A-dependent keratinocyte pyroptosis. Nat Commun. 2025 Nov 26;16(1):10570.
    DOI: 10.1038/s41467-025-65674-3PMID: 41298504
    Figure 2 from LaRock et al. 2025: S. aureus induces GSDMA-dependent cell death, shown via western blot of gasdermin cleavage and lysis assays across GSDMA family members and ScpA/SpeB protease conditions.
    Figure 2, LaRock et al. 2025, Nat Commun.
  • 2023
    Kuiack RC, Tuffs SW, Dufresne K, Flick R, McCormick JK, McGavin MJ.  The fadXDEBA locus of Staphylococcus aureus is required for metabolism of exogenous palmitic acid and in vivo growth. Mol Microbiol. 2023 Sep;120(3):425-438.
    DOI: 10.1111/mmi.15131PMID: 37501506
    Figure 9 from Kuiack et al. 2023: schematic diagram of fatty acid metabolism in S. aureus, integrating FarE, OhyA, FakA/FakB, and the FadDEBA pathway.
    Figure 9, Kuiack et al. 2023, Mol Microbiol.
  • 2023
    Bonn CM, Rafiqullah IM, Crawford JA, Qian YM, Guthrie JL, Matuszewska M, Robinson DA, McGavin MJ.  Repeated Emergence of Variant TetR Family Regulator, FarR, and Increased Resistance to Antimicrobial Unsaturated Fatty Acid among Clonal Complex 5 Methicillin-Resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2023 Mar 16;67(3):e0074922.
    DOI: 10.1128/aac.00749-22PMID: 36744906
    Figure 2 from Bonn et al. 2023: phylogenetic tree of the S. aureus CC5 population showing distribution of FarR variants, country, sequence type, and mecA presence.
    Figure 2, Bonn et al. 2023, Antimicrob Agents Chemother.
  • 2020
    Kuiack RC, Veldhuizen RAW, McGavin MJ.  Novel Functions and Signaling Specificity for the GraS Sensor Kinase of Staphylococcus aureus in Response to Acidic pH. J Bacteriol. 2020 Oct 22;202(22):e00219-20.
    DOI: 10.1128/JB.00219-20PMID: 32868405
    Figure 5 from Kuiack et al. 2020: growth of USA300, ΔgraS, and complemented strains under acidic pH and polymyxin B, or in the presence of linoleic or palmitic acid.
    Figure 5, Kuiack et al. 2020, J Bacteriol.
  • 2020
    El-Halfawy OM, Czarny TL, Flannagan RS, Day J, Bozelli JC Jr, Kuiack RC, Salim A, Eckert P, Epand RM, McGavin MJ, Organ MG, Heinrichs DE, Brown ED.  Discovery of an antivirulence compound that reverses β-lactam resistance in MRSA. Nat Chem Biol. 2020 Feb;16(2):143-149.
    DOI: 10.1038/s41589-019-0401-8PMID: 31768032
    Figure 2 from El-Halfawy et al. 2020: transposon mutant screen and binding assays identifying GraR as the target of antivirulence compound MAC-545496.
    Figure 2, El-Halfawy et al. 2020, Nat Chem Biol.
  • 2019
    Goncheva MI, Flannagan RS, Sterling BE, Laakso HA, Friedrich NC, Kaiser JC, Watson DW, Wilson CH, Sheldon JR, McGavin MJ, Kiser PK, Heinrichs DE.  Stress-induced inactivation of the Staphylococcus aureus purine biosynthesis repressor leads to hypervirulence. Nat Commun. 2019 Feb 15;10(1):775.
    DOI: 10.1038/s41467-019-08724-xPMID: 30770821
    Figure 4 from Goncheva et al. 2019: a purR mutant of S. aureus is hypervirulent in vivo, dependent on fibronectin-binding proteins FnbA/FnbB, shown via survival, weight loss, bacterial burden, and histology.
    Figure 4, Goncheva et al. 2019, Nat Commun.
  • 2019
    Alnaseri H, Kuiack RC, Ferguson KA, Schneider JET, Heinrichs DE, McGavin MJ.  DNA Binding and Sensor Specificity of FarR, a Novel TetR Family Regulator Required for Induction of the Fatty Acid Efflux Pump FarE in Staphylococcus aureus. J Bacteriol. 2019 Jan 11;201(3):e00602-18.
    DOI: 10.1128/JB.00602-18PMID: 30455282
    Figure 2 from Alnaseri et al. 2019: mapping of structural features in the farER intergenic region and EMSA analysis of FarR DNA-binding specificity.
    Figure 2, Alnaseri et al. 2019, J Bacteriol.
  • 2018
    Flannagan RS, Kuiack RC, McGavin MJ, Heinrichs DE.  Staphylococcus aureus Uses the GraXRS Regulatory System To Sense and Adapt to the Acidified Phagolysosome in Macrophages. mBio. 2018 Jul 17;9(4):e01143-18.
    DOI: 10.1128/mBio.01143-18PMID: 30018109
    Figure 3 from Flannagan et al. 2018: GraS is required for S. aureus proliferation inside macrophages, shown via fluorescence microscopy of intracellular bacterial replication in RAW 264.7 and human macrophages.
    Figure 3, Flannagan et al. 2018, mBio.

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